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The hepatotoxicity of murine influenza A virus.
Murine influenza A viruses are divided into two subtypes, H1 and H2. The H1 viruses cause respiratory disease in mammals, with subtype H1N1 causing endemic human influenza (this subtype is also referred to as ‘human seasonal influenza’) and subtype H1N1 (‘avian influenza’) is responsible for recent, worldwide epizootic outbreaks in poultry. The H2 viruses cause respiratory disease in mice and there is some evidence that these viruses may also cause damage to the liver. In an in vivo study, the level of hepatitis was increased in infected mice and was correlated with an increase in the number of differentially expressed liver genes. In a similar study, viral replication was increased in infected mice and was again correlated with an increase in the number of differentially expressed genes. Therefore, this investigation has identified a number of potential, host gene-viral gene interactions in virus-induced hepatitis, including the mitogen-activated protein kinase kinase genes and in vitro experiments indicate that both subtypes can induce cell-cycle arrest and apoptosis.Q:
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Primary hepatocytes were isolated from Sprague-Dawley rats fed a normal diet or the Triton WR 1339 diet, which produces both hyperlipidemia and diabetes mellitus. Diabetic, hyperlipidemic, and normal hepatocytes were incubated with either [1-14C]oleic or [1-14C]palmitic acid. Both radioactive fatty acids were associated with triglycerides, resulting in less than 5% released fatty acids. The radioactivity associated with free fatty acids increased in diabetic and hyperlipidemic hepatocytes. Also, in the diabetic and/or hyperlipidemic hepatocytes, the radioactivity associated with triglycerides decreased. These observations are consistent with the presence of increased fatty acid synthesis and decreased fatty acid degradation in the diabetic and/or hyperlipidemic hepatocytes. This is the first time that fatty acid synthesis and degradation have been compared in normal, diabetic, and/or hyperlipidemic hepatocytes.Almas Aghad
Almas Aghad (, also Romanized as Ālmās Āghād and Ālmās Āghad; also known as Almaz Āghād) is a village in Astaneh-ye Ashrafiyeh Rural District, Central District, Varzaqan County, East Azerbaijan Province, Iran. At the 2006 census, its population was 829, in 177 families.
References
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